pentobarbital will decrease the level or outcome of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.pentobarbital will lower the extent or influence of prednisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.benzhydrocodone/acetaminophen and pentobarbital both boost s